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Guava leaves are widely used for their antidiabetic properties. However, each capsules containing 500 mg of a phytodrug developed from guava leaves (standardized concentration of flavonoids estimated as 1 mg of quercetin per 500mg) every 8 hours for 3 days was used in one clinical trial of adults with acute diarrheic disease; 10 ml of psidium guajava tincture dissolved in water taken every 8 hours has also been used in a study of adults with acute diarrhea. Due to the presence of citric and malic acids in guava leaves have a pH level of around 3-4. This cause the guava leaves is acidic. Therefore, several studies have also shown that guava leaf extract is antimicrobial. This means that it can neutralize harmful microbes in your gut that cause diarrhea. Based on our observations, it can be concluded that guava leaves demonstrated potent antidiarrheal efficacy. Based on the findings we obtained, can be concluded that people starting to find traditional medicine to reduce using medicine that contains drugs and chemicals. This is why an organic product is safer to be taken back to basic nature base.